The three polys plus weight loss, sick day rules, and why a sudden behavior change means check the glucose.
Type 1 is autoimmune destruction of the beta cells. There is no insulin at all, so glucose cannot get into cells — the body is starving in a sea of sugar.
Polyuria, polydipsia, polyphagia AND weight loss. A child eating more and losing weight has type 1 until proven otherwise.
New bedwetting in a previously dry child, or a toddler soaking through diapers. Also constant thirst, tiredness, irritability, and blurred vision.
Many present already in DKA: Kussmaul breathing, fruity breath, vomiting, and abdominal pain that can be mistaken for appendicitis.
| Type 1 | Type 2 | |
|---|---|---|
| Onset | Sudden, weeks | Gradual |
| Body habitus | Often thin, recent weight loss | Usually overweight |
| Insulin | Always required | Diet, metformin, sometimes insulin |
| Ketones | Common at diagnosis | Uncommon |
| Acanthosis nigricans | No | Yes — dark velvety neck creases |
In a young child, low blood sugar often looks like a sudden change in behavior — irritable, tearful, silly, or unusually quiet.
Also: shaky, sweaty, pale, hungry, headache, confused.
When you cannot tell high from low, treat as LOW. Hypoglycemia kills in minutes; hyperglycemia takes hours.
15 g of fast carbohydrate → wait 15 minutes → recheck. Repeat until above 70, then a snack with protein.
15 g looks like: 4 oz juice 3 glucose tabs 1 tbsp honey (over 12 months)
If the child is unconscious or cannot swallow, nothing goes in the mouth. IM glucagon or IV dextrose.
Exercise lowers glucose, sometimes for hours afterwards.
| Insulin | Onset | Peak | Duration |
|---|---|---|---|
| Lispro / aspart | 15 min | 1 h | 3–4 h |
| Regular | 30 min | 2–3 h | 5–8 h |
| NPH | 1–2 h | 4–12 h | 12–18 h |
| Glargine | 1–2 h | No peak | ~24 h |
Peak time is when hypoglycemia happens — that is the only reason to memorize these.
Glargine is never mixed with another insulin. When mixing NPH and regular: clear before cloudy.
Rotate injection sites to prevent lipohypertrophy, which makes absorption unpredictable.
Screening: HbA1c every 3 months; annual eye, kidney, lipid and thyroid checks.