Meningitis is inflammation of the membranes that wrap the brain and spinal cord. The
infection itself is bad; what kills people is the swelling inside a skull that cannot expand. Two
facts do most of the work on an exam: bacterial meningitis is a droplet-precaution emergency, and the
first thing to change is not the neck or the fever — it is the patient’s level of consciousness.
🧪 CSF tells you whichBacterial = Bad cloudy, neutrophils, protein ↑, glucose LOW. Viral = Very clear, lymphocytes, glucose NORMAL.
🦠
WHAT IT IS & HOW IT GETS THERE
STEP 1 · CAUSE
Three membranes, one fluid-filled space, and a rigid box that will not let any of it swell.
From your lecture. The chain your lecturer drew: inflammation → swelling → raised ICP → death. That is why the neck pain and the photophobia matter.
🧅 The meninges — the layers that get inflamed
Meningitis = inflammation of the meninges, the lining of the brain and spinal cord. The
infection lives in the subarachnoid space, the CSF-filled gap between the arachnoid and the pia —
which is exactly where you put the lumbar-puncture needle to sample it.
🧠 “PAD” from the inside out: Pia · Arachnoid · Dura. Pia is the soft skin on the brain; the dura is the tough leather on the outside.
🚨 BACTERIAL — “Bad news, most contagious”
The medical emergency. Onset is fast — hours. Common organisms in adults include
Streptococcus pneumoniae and Neisseria meningitidis; Haemophilus influenzae type b in
unimmunized children; Listeria at the extremes of age.
Untreated it can kill within a day. Antibiotics are started immediately — after blood
cultures, and without waiting for the LP result if the LP will be delayed.
🧠 Bacterial = Bad. Bad = cloudy CSF, Bad = droplet precautions, Bad = give antibiotics NOW.
🧫 VIRAL — “Very common, most tested”
Also called aseptic meningitis. Usually enteroviruses. It is far more common, generally
much milder, and most people recover with supportive care — fluids, antipyretics, analgesia, rest,
and a dark quiet room.
The patient still feels awful: headache, photophobia, stiff neck, fever. You cannot tell viral from
bacterial by symptoms alone — that is what the CSF is for.
🧠 Viral = Very clear CSF, Very common, and glucose stays Very normal.
🧭 Other causes
Fungal — especially Cryptococcus in immunocompromised patients (HIV)
Head trauma — a basilar skull fracture creates a direct road in for bacteria
Neurosurgery, shunts and invasive devices
Spread from a nearby infection — sinusitis, otitis media, mastoiditis
Autoimmune / inflammatory disease such as lupus
SEE ALSO Basilar skull fracture and CSF leak are on NG-247 · Head Injury — that clear drainage is a meningitis risk, which is why you never pack the ear or nose.
🧠 Any hole into the CSF is a meningitis waiting to happen.
🫂 Who is at risk
Crowded living — college dorms, military barracks, dormitory-style housing
🧠 Freshman in a dorm with fever, headache and a stiff neck = meningococcal until proven otherwise. That is the exam’s favorite patient.
⚠️ Why this becomes an ↑ ICP emergency
Organism reaches the subarachnoid space
▼
Massive inflammatory response · pus fills the CSF space
▼
Cerebral edema + CSF flow is obstructed
▼
↑ INTRACRANIAL PRESSURE inside a rigid skull
▼
Seizures · ↓ LOC · herniation · DEATH
That chain is why every intervention on this page is about lowering pressure and lowering
stimulation at the same time as killing the organism.
SEE ALSO The full early-vs-late ICP picture and Cushing’s triad are drawn out on NG-247 · Head Injury.
🧠 “Infection is the cause; PRESSURE is what kills.”
🔎
SIGNS & THE TWO NAMED TESTS
STEP 2 · CLUES
Learn the two eponyms precisely — students lose marks by swapping them, and the exam knows it.
🅷 The classic picture
🧠 Three H’s: Headache · Hard neck · High temp. Add photophobia and you have the whole classic presentation.
⭐ In ADULTS, what changes first
Agitation, irritability and altered level of consciousness are the first sign — the same
earliest sign as any rising intracranial pressure.
Restless → irritable → confused → drowsy
Severe headache, photophobia
Nuchal rigidity — the neck resists forward flexion
Fever, chills, nausea, vomiting
Seizures
Progression to coma and death if untreated
🧠 Do not wait for the stiff neck. New confusion + fever in a headachy patient is enough to escalate.
🚨 The rash you must not miss
Meningococcal disease can produce a petechial or purpuric rash that does not blanch
when you press on it (the glass test). It means bacteria and clotting factors are in the bloodstream.
A non-blanching rash with fever = medical emergency, escalate immediately. It can progress to
widespread purpura, DIC and adrenal hemorrhage (Waterhouse–Friderichsen syndrome).
🧠 “Press a glass on it.” If the spots stay visible through the glass, that is not a rash — that is bleeding under the skin.
🦵 KERNIG’S SIGN — bend the hip, then straighten the knee
Definition: with the patient supine, flex the hip to 90° with the knee
bent, then attempt to extend the knee. Pain and resistance in the hamstring and lower back is a
positive Kernig’s sign.
🧠 KERNIG = KNEE. Both start with K. You do something to the knee.
🪑 BRUDZINSKI’S SIGN — flex the neck, watch the legs
Definition: with the patient supine, passively flex the neck (chin toward chest). If the
hips and knees flex involuntarily — you never touched the legs — that is a positive
Brudzinski’s sign.
Both signs happen because inflamed meninges are stretched by the movement, and the body reflexively
pulls away from that stretch.
🧠 BRUDZINSKI = BEACH CHAIR. Both start with B. Bend the neck, the Body folds up.
🎯 The Kaplan scenario, decoded
“Suspected meningitis — when the neck flexes, the hip and knee also flex. Priority action?”
That description is a positive Brudzinski’s sign. The action is to
report the finding to the provider immediately — it confirms meningeal irritation in a
patient who may be hours from deteriorating.
🧠 If the stem describes the maneuver instead of naming it, translate it first — then answer.
⚠️ Both signs can be NEGATIVE and it still be meningitis
Kernig and Brudzinski are specific but not sensitive — a positive one is meaningful, a negative
one rules nothing out. They are also unreliable in infants, the very old, and the deeply obtunded.
Never let a negative Kernig talk you out of escalating a febrile patient with a headache and new
confusion.
🧠 Positive helps you. Negative helps you not at all.
👶 THE PEDIATRIC PICTURE — different signs entirely
🧠 “Bulging, shrill, and hates being held.” A baby with meningitis is soothed by nothing — being picked up and moved makes the headache worse, which is the opposite of a normal fussy baby.
🧪
DIAGNOSIS — CT, THEN LUMBAR PUNCTURE
STEP 3 · CONFIRM
The CSF is the answer sheet. Getting to it safely is the nursing part.
💉 The lumbar puncture
🧠 “Curl like a shrimp.” Knees to chest, chin to chest — that is what opens the spaces between the vertebrae.
🚨 CT scan is usually done FIRST
If intracranial pressure is already high, draining CSF from the lumbar space creates a pressure
gradient that can pull the brain downward — herniation.
So a CT head is obtained first when there are signs of raised pressure or a mass: papilledema, new
focal neurological deficit, seizure, severely depressed LOC, or immunocompromise.
Never send a patient for a lumbar puncture on your own initiative when they have focal deficits or a rapidly falling level of consciousness.
🧠 “CT before tap.” Look before you drain.
✅ Nursing care around the LP
B
Before: consent, explain, have the patient empty the bladder, baseline neuro check and vitals.
D
During: help hold the position — side-lying knees-to-chest or sitting leaning over a table. Keep them still. Watch breathing and color.
A
After: lie flat as ordered, increase fluids, analgesia for headache, monitor the site dressing for clear drainage and check movement and sensation in the legs.
Post-LP headache is worse upright and better flat — the classic pattern. Report clear drainage
from the site, fever, or new leg weakness.
🧠 Flat and fluids. Two words cover almost all post-LP care.
🧪 CSF results — normal vs viral vs bacterial
🧠 Bacteria EAT the sugar. That is the whole trick: bacterial meningitis has a LOW CSF glucose because the organisms are consuming it. Viruses don’t, so viral glucose stays normal.
⭐ The comparison table to memorize
CSF finding
BACTERIAL
VIRAL
Normal adult
Appearance
Cloudy / turbid
Clear
Clear, colorless
WBC
↑↑↑ neutrophils
↑ lymphocytes
0–5 /mm³
Protein
HIGH ↑↑
Normal or slightly ↑
15–45 mg/dL
Glucose
LOW ↓ ⭐
NORMAL ⭐
45–80 mg/dL (≈ ⅔ of serum)
Opening pressure
HIGH ↑↑
Normal / mildly ↑
70–180 mmH₂O
Gram stain / culture
Positive
Negative
Negative
Both types raise the white cell count — so the WBC alone does not tell you which. The
glucose and the cell type do.
The numbers in the “Normal adult” column are typical adult reference ranges and vary by laboratory — always compare against the range printed on your patient’s result.
🧠 “Bad = cloudy, high protein, LOW sugar, neutrophils.” Say it as one string.
🧫 The other tests
Blood cultures — draw before antibiotics whenever possible, but never let them delay treatment in a deteriorating patient
CBC — leukocytosis with a left shift
CT or MRI head — before the LP, and to look for complications such as abscess or hydrocephalus
PCR panel on CSF — identifies viral and bacterial organisms fast
Serum electrolytes — SIADH is a recognized complication
🧠 Cultures before antibiotics — but antibiotics before perfection. Time to antibiotic drives survival.
😷
ISOLATION & NURSING CARE
STEP 4 · CARE
Protect yourself, protect the unit, then lower the pressure and the noise around the patient.
🚨 Droplet precautions — the FIRST action
🧠 PPE before assessment. If a question asks the first action for suspected bacterial meningitis, the answer is isolation — not vital signs, not the neuro check.
⭐ Droplet vs Airborne — the two lists
DROPLET · surgical mask
AIRBORNE · N95
Pertussis
Measles
Influenza
Tuberculosis
Meningitis (bacterial)
Varicella — chickenpox / shingles (disseminated)
Pneumonia
Private room · surgical mask + goggles · patient masks for transport
N95 for staff · negative-pressure room · door CLOSED · patient wears a surgical mask for transport
Meningitis is droplet, not airborne. You do not need an N95 and you do not need a
negative-pressure room — but you do need a private room and a mask before you walk in.
🧠 Drop-LET = surgical mask. Air-BORNE = N95 + negative pressure. And “MTV is in the AIR.”
🚨 Antibiotics: the clock is the treatment
In suspected bacterial meningitis, broad-spectrum IV antibiotics are started as soon as cultures are
drawn — and immediately, without waiting, if the LP will be delayed. Every hour of delay costs
outcome.
Dexamethasone is given in some adult bacterial cases to reduce the inflammatory injury; it is
typically given with or just before the first antibiotic dose.
Viral meningitis gets supportive care; antibiotics do nothing for it, but they are often started
until bacterial disease is excluded.
🧠 “Culture, then cover.” Never hold antibiotics waiting for a perfect specimen in a crashing patient.
🚨 LOW blood pressure will kill
Septic shock is a real complication of meningococcal disease. A patient admitted with bacterial
meningitis and a BP of 78/56 needs a bolus of IV isotonic fluid
(0.9% NaCl) — that is the priority action.
Perfusion pressure to the brain is MAP − ICP; hypotension on top of raised
ICP starves the brain twice over.
Low pressure — no coughing, no straining, no bending the extremities, no hip flexion
HOB elevated at least 30°, head midline
Low BP is the emergency — treat it, don’t just chart it
🧠 “Low light · low noise · low pressure · but never a low BP.” Three lows you want, one you fix.
⚡ Seizure precautions on admission
Padded side rails, bed in the lowest position
Suction and oxygen set up and working at the bedside
IV access maintained
Nothing hard or hot at the bedside; supervise ambulation
Know where the rescue benzodiazepine is
SEE ALSO Everything about what to do during a seizure is on NG-226 · Seizures.
🧠 Meningitis irritates the cortex. Assume they will seize and be set up for it before they do.
🩺 Everything else you monitor
Neuro checks + GCS on a schedule — compare with the last set
Pupils — new inequality is an emergency
Vital signs for Cushing’s triad and for septic shock (two opposite patterns)
Strict intake and output — SIADH causes dilutional hyponatremia
Sodium — falling Na⁺ lowers the seizure threshold further
Skin — look for a spreading petechial or purpuric rash at every assessment
Temperature — fever raises cerebral metabolic demand; treat it
🧠 Two BP stories: rising systolic with bradycardia = ICP. Falling BP with tachycardia = septic shock. Both can happen in the same patient.
🛡️
CONTACTS, PREVENTION & TEACHING
STEP 5 · TEACH
The people in the next bed and the roommate at home are part of your assessment.
⭐ Prophylaxis for close contacts
After meningococcal (and H. influenzae type b) meningitis, people with close, prolonged
contact need antibiotic prophylaxis — household members, intimate partners, roommates, childcare
contacts, and health-care workers who had direct exposure to respiratory secretions (mouth-to-mouth,
intubation, suctioning without a mask).
Agents used include rifampin, ciprofloxacin, or ceftriaxone. Warn about
rifampin turning urine, sweat and tears orange and staining soft contact lenses, and that it
reduces the effectiveness of oral contraceptives.
🧠 Sharing a room or sharing saliva = prophylaxis. Sharing a hallway = no. Casual contact does not qualify.
💉 Vaccines actually prevent this
Meningococcal conjugate (MenACWY) — routine for adolescents; recommended for college
first-years in residence halls, military recruits, asplenia and travel to high-risk areas
Meningococcal B (MenB) — additional series for some adolescents and high-risk groups
Pneumococcal — infants, older adults and chronic disease
Haemophilus influenzae type b (Hib) — routine childhood series
🧠 “Dorm room = MenACWY.” If the stem mentions moving into a residence hall, immunization is the teaching point.
🏠 Discharge teaching
Finish the entire antibiotic course even once feeling better
Expect fatigue, headaches and poor concentration for weeks
Return for fever, new headache, seizure, confusion, new weakness or a rash
Attend follow-up hearing testing — sensorineural hearing loss is a common sequela, especially in children
Household contacts must take their prophylaxis
🧠 Hearing is the sequela students forget. Every child after bacterial meningitis gets an audiology follow-up.
⚠️ Complications to watch for
Raised ICP and herniation — the immediate killer
Seizures
Septic shock and DIC (meningococcemia)
SIADH → hyponatremia → more seizures
Hydrocephalus from blocked CSF flow
Hearing loss, cognitive and learning deficits
Waterhouse–Friderichsen syndrome — adrenal hemorrhage with circulatory collapse