This is the answer key — but not a list of answers. Each of the four gases from
NG-138 is drawn as a lit-up route through the
decision tree, so you can see exactly where the reasoning turned. Then: where each disorder comes from,
what to do about it, the mixed-disorder trap, and the oxygenation half of the gas that everyone forgets.
The method is on NG-092.
1️⃣ 7.32 · 55 · 42Respiratory acidosis, PARTIALLY compensated.
All three numbers abnormal.
2️⃣ 7.55 · 49 · 35Metabolic alkalosis, PARTIALLY compensated.
The high CO₂ is the rescue, not the cause.
3️⃣ 7.37 · 52 · 32Respiratory acidosis, FULLY compensated.
Normal pH on the acid side of 7.40.
4️⃣ 7.43 · 43 · 33Metabolic alkalosis, FULLY compensated.
Normal pH on the alkaline side of 7.40.
✅
PART 1 · THE FOUR ANSWERS
EVERY TURN SHOWN
Follow the gold route with your finger. Where it lights up is where you had to make a decision.
All reference values on this page (pH 7.35–7.45, PaCO₂ 35–45 mmHg, HCO₃⁻ 22–26 mEq/L) are typical adult
ranges and vary by lab — read the range printed on your own report.
🧭 First, the trick that unlocks questions 3 and 4
Two of the four gases come back with a normal pH. The half of the normal window the
pH lands in tells you what the original disorder was, because compensation never overshoots 7.40.
🧠 Below 7.40 it was an acidosis. Above 7.40 it was an alkalosis.
1️⃣ Question 1 — pH 7.32 · PaCO₂ 55 · HCO₃⁻ 42
Three abnormal numbers is the signature of partial compensation: the culprit is out
of range, the rescuer is out of range, and the pH still hasn't made it home.
Respiratory acidosis · partially compensated
🧠 The dramatic HCO₃⁻ of 42 is the rescuer, not the problem. It argues with the pH.
🩺 Question 1 — the patient behind the numbers
A CO₂ retainer who is losing ground. The kidneys have had days to bank bicarbonate (HCO₃⁻ 42 is a
long-term adaptation), but the CO₂ has now climbed faster than they can keep up.
Think COPD with an acute exacerbation on top of chronic retention, or a chronic retainer who has
been over-sedated.
Priorities: improve ventilation — position upright, treat the reversible cause (bronchospasm,
secretions, infection, sedation), escalate for possible non-invasive ventilation.
Never assume a sleepy CO₂ retainer is “settled for the night.”
🧠 Partial compensation + a deteriorating patient = the rescue is losing. Escalate.
2️⃣ Question 2 — pH 7.55 · PaCO₂ 49 · HCO₃⁻ 35
The step-2 turn is the whole question here. The first abnormal partner you meet (PaCO₂ 49)
is not the culprit — it points the wrong way.
Metabolic alkalosis · partially compensated
🧠 Don't grab the first abnormal number. Grab the one that AGREES with the pH.
🩺 Question 2 — the patient behind the numbers
Base gained, or acid lost. Something has been taking hydrogen ions out of this patient.
Classic causes: protracted vomiting, nasogastric suction, over-use of antacids or
bicarbonate, loop and thiazide diuretics, hypokalemia.
Expect the alkalosis picture: tingling, muscle cramps, twitchiness, tetany, arrhythmias —
alkalosis lowers ionized calcium and drives potassium into cells.
Priorities: stop the loss (antiemetics, review the NG suction and diuretics), replace fluid and
electrolytes as prescribed, and check potassium, chloride and calcium.
The high CO₂ is deliberate hypoventilation. Do not “correct” it — it is the only help this patient has.
🧠 Vomit and suction throw acid away. What's left behind is base.
3️⃣ Question 3 — pH 7.37 · PaCO₂ 52 · HCO₃⁻ 32
The step-1 box that lights up is NORMAL pH — and the route keeps going anyway.
That is the entire lesson of this question.
Respiratory acidosis · fully compensated
🧠 Normal pH + two abnormal partners = fully compensated, never “normal”.
🩺 Question 3 — the patient behind the numbers
This is the textbook chronic COPD gas. The kidneys have had days to bank bicarbonate and have
bought back a normal pH.
Very likely the patient's baseline. Compare with previous gases before you treat it as new.
The patient can look and feel completely well with these numbers.
Priorities: treat the underlying disease, not the printout. Keep an eye on their usual
oxygen target — check the plan for that individual patient.
What matters clinically is the trend: a rising CO₂ with a falling pH from this baseline is
an acute-on-chronic deterioration.
🧠 Fully compensated respiratory acidosis = old. Take a history, not fright.
4️⃣ Question 4 — pH 7.43 · PaCO₂ 43 · HCO₃⁻ 33
Only one partner is frankly abnormal here. The pH is normal, so the state is judged by the
pH — and the side of 7.40 names the disorder.
Metabolic alkalosis · fully compensated
🧠 7.41–7.45 with a high HCO₃⁻ = a compensated metabolic alkalosis.
⚠️ Question 4 — the honest nuance
The compensating PaCO₂ of 43 is sitting at the very top of normal. The
lungs are hypoventilating a little, but not enough to push the number out of range.
By the rule this course teaches — full compensation = a fully normal pH — the answer is
fully compensated.
Some references would describe the respiratory response here as incomplete, because the CO₂ has
not moved as far as expected. Both descriptions are talking about the same gas.
If you are ever unsure on an exam, say what you see: “normal pH on the alkaline side of 7.40 with a
high bicarbonate — a compensated metabolic alkalosis.”
🧠 Describe the gas, then name it. Description never loses marks.
📋 All four answers on one line each
Q
pH
PaCO₂
HCO₃⁻
Primary problem
Compensation
1
7.32 ↓
55 ↑ acid
42 ↑ base
Respiratory acidosis
Partial
2
7.55 ↑
49 ↑ acid
35 ↑ base
Metabolic alkalosis
Partial
3
7.37 (n)
52 ↑ acid
32 ↑ base
Respiratory acidosis
Full
4
7.43 (n)
43 (n)
33 ↑ base
Metabolic alkalosis
Full
In every one of the four, the culprit is the partner that agrees with the pH.
🧠 Two respiratory, two metabolic · two partial, two full. The set covers the whole grid.
🗺️
PART 2 · WHERE THEY COME FROM
CAUSES + WHAT YOU DO
Naming the gas is half the job. The other half is knowing which organ to go and look at.
🗺️ The cause map — organs on the left, causes on the right
Every acid–base disorder starts somewhere physical. Match the number on the cause to the
numbered organ on the body.
🧠 “Breathing problem or chemistry problem?” One question sorts almost every case.
🚨 Respiratory acidosis — what you actually do
Answer first: make them ventilate. This is a CO₂ problem, not simply an oxygen problem.
Sit upright, wake them, coach deep breathing and coughing, incentive spirometer.
Clear the airway — suction secretions, treat bronchospasm as prescribed.
Treat pain so they can take a full breath; review sedation and opioids.
Escalate early for non-invasive ventilation if the CO₂ is climbing and the patient is tiring.
Monitor level of consciousness — a falling LOC with a rising CO₂ is an emergency.
🧠 Move air, not just oxygen.
💨 Respiratory alkalosis — what you actually do
Answer first: find out why they are breathing so hard.
Rule out the dangerous causes first — hypoxia, pulmonary embolism, sepsis, pain, fever — before
you call it anxiety.
If it is anxiety: stay with them, coach slow breathing, reduce stimulation.
If they are ventilated: the settings may be doing it — report the gas.
Expect and manage the symptoms: tingling, dizziness, carpopedal spasm.
🧠 Hyperventilation is a symptom. Treat the reason, not the rate.
🚨 Metabolic acidosis — what you actually do
Find the acid. Blood glucose and ketones (DKA), lactate and perfusion (shock, sepsis),
renal function, and a stool history (diarrhea).
Restore perfusion — fluids as prescribed; a poorly perfused patient keeps making lactate.
Insulin and fluids for DKA per protocol; replace ongoing GI losses.
Watch the potassium and the cardiac monitor — acidosis drives K⁺ out of cells, and correcting
the acidosis drives it back in.
Leave the Kussmaul breathing alone. It is the only compensation they have.
🧠 Perfuse, treat the cause, watch the K⁺.
🤢 Metabolic alkalosis — what you actually do
Stop the loss: antiemetics as prescribed, review nasogastric suction, review diuretics and
antacid use.
Replace fluid and electrolytes as prescribed — this is very often a volume and chloride problem.
Correct the potassium. Hypokalemia both causes and maintains a metabolic alkalosis.
Monitor for tetany, cramps and arrhythmias; keep the patient on a monitor if the potassium is low.
🧠 Vomiting is not just fluid loss — it is acid loss.
🧠 The pattern that names most cases before you see a gas
The story
Predict this gas
Post-op, sleepy, had opioids
Respiratory acidosis
Panicking, tingling fingers, fast deep breaths
Respiratory alkalosis
New diabetic, thirsty, fruity breath, deep sighing breathing
Metabolic acidosis (DKA)
Vomiting for three days, or on continuous NG suction
Metabolic alkalosis
Long-standing COPD, comfortable, normal pH
Fully compensated respiratory acidosis
Profound shock or a cardiac arrest
Mixed acidosis (respiratory + metabolic)
🧠 Read the story before you read the numbers. The gas usually confirms what you already suspected.
🚨
PART 3 · THE HARDER CASES
MIXED, EXPECTED, OXYGEN
Three things that turn an easy ABG question into a hard one.
🚨 Compensated vs mixed — the two-second check
Put a finger on PaCO₂ and a finger on HCO₃⁻. Opposite sides means someone is rescuing.
Same side means nobody is, and the pH falls off a cliff.
🧠 Opposite = rescue. Same = disaster.
🚨 Mixed disorders — when to worry
Both partners abnormal in the same acid–base direction = a combined disorder.
The commonest one you will meet: cardiac arrest — the patient is not ventilating (CO₂ up)
and is not perfusing (lactate up, HCO₃⁻ down).
Also seen in severe sepsis, in opioid overdose with shock, and in a patient with COPD who
develops a severe metabolic acidosis.
Recognize it by the severity of the pH — mixed disorders produce the most extreme pH values you
will ever see.
Never label a mixed picture “partially compensated”. Nothing is compensating.
🧠 Two problems pushing the same way = a resuscitation, not a lab result.
⭐ “Is the compensation about right?”
You are not usually asked to calculate this at this stage, but the reasoning is worth having.
Compensation should be in the right direction and roughly proportional to the problem.
A large primary problem with only a tiny partner change suggests the rescuing organ cannot
respond — for example, kidneys that are failing, or lungs too weak to hyperventilate.
Compensation in the wrong direction is not compensation at all — it is a second disorder.
If your course teaches specific expected-compensation formulas, use theirs; they vary between texts.
🧠 Right direction, sensible size. Anything else means a second problem.
🫁 The oxygenation half of the gas — the bit everyone forgets
Acid–base and oxygenation are two separate questions on the same printout. The flat top of
the curve is why a saturation of 95% and one of 99% are almost the same thing — and why 88% is not.
SEE ALSO Hypoxia, oxygen delivery devices and target
saturations are covered on NG-006 Hypoxia & O₂ Devices.
🧠 60 and 90 travel together — PaO₂ 60 mmHg ≈ SaO₂ 90%, and that is the edge.
✅ Hypoxemia vs hypoxia — not the same word
Hypoxemia = low oxygen in the blood — that is what PaO₂ and SaO₂ measure.
Hypoxia = not enough oxygen reaching the tissues. You can be hypoxic with a normal PaO₂
(severe anemia, shock, carbon monoxide poisoning, cyanide).
So a normal-looking oxygen number does not prove the tissues are being oxygenated.
The earliest clinical sign of hypoxia is usually restlessness and anxiety — long before cyanosis.
🧠 -emia is in the blood. Hypoxia is in the cells.
⚠️ Things that make an ABG lie
Air bubbles left in the syringe — they change the gas values.
Delay in getting the sample to the lab — follow local policy on transport and icing.
Venous blood drawn by mistake — the picture looks falsely acidotic with a high CO₂.
No record of the oxygen the patient was on — the PaO₂ becomes uninterpretable.
Comparing to the wrong baseline — a chronic retainer's “abnormal” gas may be their normal.
🧠 No bubbles · straight to the lab · write down the FiO₂.
🎯
PART 4 · FINAL DRILL
PROVE IT
If you can do these ten without the tree, you can do them in an exam.
🎯 Ten gases — cover, answer, check
1 · pH 7.28 · PaCO₂ 58 · HCO₃⁻ 25
pH acid · CO₂ high = acid (match, lungs) · HCO₃⁻ normal.
Respiratory acidosis, uncompensated.2 · pH 7.52 · PaCO₂ 28 · HCO₃⁻ 23
pH base · CO₂ low = base (match, lungs) · HCO₃⁻ normal.
Respiratory alkalosis, uncompensated.3 · pH 7.30 · PaCO₂ 30 · HCO₃⁻ 16
pH acid · CO₂ low = base (no match) · HCO₃⁻ low = acid (match, metabolic). The low CO₂ is the lungs
helping. pH still abnormal. Metabolic acidosis, partially compensated.4 · pH 7.38 · PaCO₂ 60 · HCO₃⁻ 35
pH normal on the acid side of 7.40 · CO₂ high = acid (match) · HCO₃⁻ high = the rescuer.
Respiratory acidosis, fully compensated — the chronic COPD picture.5 · pH 7.48 · PaCO₂ 42 · HCO₃⁻ 32
pH base · CO₂ normal · HCO₃⁻ high = base (match, metabolic).
Metabolic alkalosis, uncompensated.6 · pH 7.12 · PaCO₂ 62 · HCO₃⁻ 15
pH severely acid · CO₂ high = acid and HCO₃⁻ low = acid. Both partners on the same side.
Mixed (combined) respiratory and metabolic acidosis — a resuscitation picture.7 · pH 7.41 · PaCO₂ 30 · HCO₃⁻ 19
pH normal on the alkaline side of 7.40 · CO₂ low = base (match) · HCO₃⁻ low = the kidneys dumping base
to help. Respiratory alkalosis, fully compensated — think chronic hyperventilation or altitude.8 · pH 7.20 · PaCO₂ 38 · HCO₃⁻ 12 in a new diabetic
pH acid · CO₂ normal · HCO₃⁻ very low = acid (match, metabolic).
Metabolic acidosis, uncompensated — consistent with DKA. Expect Kussmaul respirations to start
and the CO₂ to fall on the next gas.9 · pH 7.34 · PaCO₂ 50 · HCO₃⁻ 30 · PaO₂ 55 on room air
Acid–base: pH acid · CO₂ high = acid (match) · HCO₃⁻ high = rescuer, pH still low →
respiratory acidosis, partially compensated. Separately, PaO₂ 55 is hypoxemia — below the
60 mmHg cliff. Both problems need reporting.10 · pH 7.40 · PaCO₂ 40 · HCO₃⁻ 24
Everything inside its reference range. A genuinely normal ABG.
⭐ The 30-second script for any ABG
1
“The pH is ___ — that's an
acidosis / alkalosis (or normal, on the ___ side of 7.40).”
2
“The ___ agrees with it, so this is
respiratory / metabolic.”
3
“The ___ has moved the other way, so it is
uncompensated / partially / fully compensated.”
ANSWER KEY — the filled-in decision path for all four gases, plus the causes of each
disorder, the expected-compensation check, oxygenation, and the traps.
🧠 Method → Practice → Key. Do them in that order and the fourth ABG stops being scary.