The basic metabolic panel is the single most ordered blood test in the hospital, and it
is the one you will be handed at 06:00 with a pen and no explanation. This page teaches it the way it is
actually written — as a fishbone — then goes value by value, then teaches the two patterns that
carry most of the exam questions: what the BUN : creatinine ratio means, and what CO₂ tells you
about acid–base.
🧪 The 8Na · K · Cl · CO₂ · BUN · creatinine · glucose ·
calcium. Six in the fishbone, glucose on the point, calcium alongside.
💓 K⁺ is the priority3.5–5.0 mEq/L.
Peaked T = high. Flat T + U = low. Never IV push.
🫘 BUN : CrOver 20:1 = DRY
(pre-renal). About 10–15:1 with both raised = the kidney is hurt.
🧠 The four jobsSodium swells · Potassium pumps ·
Calcium contracts · Magnesium mellows.
⚠️ Read this before you memorize a single number. Every value on this page is a typical adult reference range — ranges vary by laboratory, so always use the range printed on your patient’s result. Critical-value cut-offs vary even more: every facility publishes its own critical list and its own call-back policy. Learn the direction and the meaning; verify the exact digits locally.
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PART 1 · THE EIGHT VALUES
WHAT IS IN THE PANEL
One tube, eight numbers, and a shorthand you will see on every whiteboard.
Figure 1 — the fishbone shorthand. Learn the positions, not just the numbers: on a real ward you will be shown this scribble long before you see a printed report.
🧪 The eight values, with their typical adult ranges
Sodium Na⁺135–145 mEq/Lswells the body with fluid
Potassium K⁺3.5–5.0 mEq/Lpumps the heart · PRIORITY
Chloride Cl⁻97–107 mEq/Lcopies sodium · acid–base
CO₂ / HCO₃⁻22–26 mEq/Lthe base · buffers the blood
Typical adult reference ranges — ranges vary by laboratory, so always use the range printed on your patient’s result.
🧠 “Never Kick Cats Cruelly, Buy Cats Great Catnip.” Na · K · Cl · CO₂ · BUN · Creatinine · Glucose · Calcium — the eight, in fishbone order.
⭐ BMP vs CMP — what the extra letters buy you
BMP (basic) — 8 values
CMP (comprehensive) — 14 values
Na · K · Cl · CO₂ BUN · creatinine · glucose · calcium
Everything in the BMP plus the liver: albumin 3.5–5.0 g/dL · total protein · total bilirubin · ALT · AST · ALP
Order a BMP for fluid, electrolyte and kidney questions. Order a CMP when the liver, nutrition or a hepatotoxic drug is part of the picture.
🧠 Basic = body water and kidneys. Comprehensive = complete, liver included.
⏱️ When is the BMP drawn — and does it need fasting?
Routine daily labs are usually drawn in the early morning so the provider has them on rounds.
Glucose is the value affected by food. A fasting glucose needs roughly 8 hours with nothing but water; a random glucose is still useful, just interpreted differently.
After any change — a new diuretic, new IV fluids, dialysis, a blood transfusion, vomiting or diarrhea — expect a repeat panel.
Know why it was ordered. “Daily BMP” on a client started on furosemide is really a potassium watch.
🧠 Ask yourself: which single value is this panel really being drawn for? There is almost always one.
Figure 8 — all eight values on their own axis. This is the figure to photograph. Cover the writing and see whether you can say what happens at each end.
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PART 2 · THE TUBE AND THE DRAW
BEFORE THE NUMBER EXISTS
Half of “abnormal” results are collection problems. Learn what breaks a sample.
Figure 2 — the tube rack in order of draw. The cap color is not decoration: it tells you which additive is inside, and the additive decides which test the tube can be used for.
🩸 Which tube for which panel
Cap
Additive
What it is for
Light blue
Sodium citrate
Coagulation — PT/INR, aPTT. Must be filled to the line.
Gold / SST
Clot activator + gel
Serum chemistry — BMP, CMP, troponin, lipids
Green
Lithium heparin
Plasma chemistry — BMP, ammonia
Lavender
EDTA
CBC — H&H, WBC, platelets, HbA1c
Gray
Fluoride oxalate
Glucose / lactate — stops the cells consuming the sugar in the tube
Pink
EDTA
Blood bank — type & screen, crossmatch
Colors follow common practice — confirm against your own facility’s specimen chart.
🧠 The blue coag tube must be filled to the line — the citrate-to-blood ratio is fixed. An under-filled blue tube gives a falsely prolonged PT/aPTT.
🚨 Hemolysis — the fake critical potassium
Answer first: a hemolysed sample falsely RAISES potassium. Red cells are packed with potassium; burst them and it spills into the serum.
Causes: a traumatic or slow draw, too small a needle, squeezing a fingerstick, shaking the tube instead of gently inverting it, an under-filled tube.
Never ignore a critical potassium just because you suspect hemolysis. Report it AND redraw per policy — both.
🧠 Hemolysis also falsely raises phosphate and magnesium and falsely lowers sodium. Anything stored inside the cell goes up when the cell breaks.
⚠️ Three more ways to ruin a good specimen
Drawing above a running IV. The sample is diluted by whatever is in the bag — draw from the opposite arm, or below the site with the infusion paused per policy.
Leaving the tourniquet on too long. Prolonged stasis concentrates the sample and raises potassium and calcium. Release it within about a minute.
Filling out of order. Additive carry-over — EDTA into a chemistry tube falsely lowers calcium and raises potassium.
🧠 Right arm, right tube, right order, right fill. Four rights, and the number you get is the number the patient actually has.
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PART 3 · THE ELECTROLYTES
FOUR JOBS, FOUR IONS
Sodium swells, potassium pumps, chloride copies, calcium contracts — and magnesium mellows from just off-panel.
Figure 3 — sodium changes cell size because water follows it. Everything sodium does to a patient follows from this one picture.
🧂 SODIUM — “sodium swells the body with fluid”
Range: 135–145 mEq/L. It is the main cation OUTSIDE the cell, and it drags water with it — so it sets blood volume and blood pressure.
LOW — hyponatremia“Low and slow.” Headache, confusion, mental status change, seizures, coma. Causes: excess water, SIADH, vomiting and diarrhea, diuretics, heavy sweating.
HIGH — hypernatremia“Big and bloated, dry inside.” Extreme thirst, dry sticky tongue, flushed skin, increased muscle tone, agitation. Causes: water loss, no access to water, diabetes insipidus, DKA, too much salt.
🧠 “Salt low = brain swells. Salt high = brain shrivels.” Sodium questions are neuro questions.
Potassium is the priority electrolyte — either direction can stop the heart. Range: 3.5–5.0 mEq/L. The main cation INSIDE the cell. Small changes make big rhythm problems, which is why it is the priority electrolyte.
HIGH — hyperkalemiaTall peaked T waves, then a widening QRS. Tingling then weakness. Hyperactive bowel sounds. Causes: renal failure, K-sparing diuretics, ACE inhibitors/ARBs, acidosis, crush injury and burns.
LOW — hypokalemiaFlat T wave, ST depression, U wave. Shallow respirations, weak legs, constipation and ileus. Causes: loop and thiazide diuretics, vomiting, diarrhea, NG suction, insulin, alkalosis.
🧠 “High and PEAKED, low and FLAT with a U.” One sentence covers both strips.
Figure 4 — the four hyperkalemia treatments and where each one sends the potassium. Notice that only two of the four actually remove any.
✅ Replacing potassium safely — the rules
Never IV push. Always diluted, always on a pump.
Commonly a maximum of 10–20 mEq per hour peripherally, with a rhythm monitored.
Check urine output first — you cannot excrete what you cannot pass.
Burning at the site: slow the rate and check the site; tell the provider.
Oral potassium goes with food and a full glass of water.
If the potassium will not come up, check the magnesium.
🧠 “Fix the mag, then the K will lag no more.” Refractory hypokalemia is usually a magnesium problem wearing a potassium costume.
🧪 CHLORIDE — “chloride copies sodium”
Range: 97–107 mEq/L. It follows sodium almost everywhere, so a low sodium usually comes with a low chloride.
Where they differ is acid–base: high chloride pushes toward metabolic acidosis (lots of normal saline, dehydration) and low chloride toward metabolic alkalosis (vomiting, NG suction, loop diuretics).
🧠 Chloride is the electrolyte nobody revises and every so often the exam asks about. Cl⁻ copies Na⁺; the exception is acid–base.
🦴 CALCIUM — “calcium contracts the muscles”
Range: 9.0–10.5 mg/dL. The three B’s: Bones, Bloodletting (clotting) and Beats.
Albumin matters. About half the calcium in blood travels bound to albumin, so a client with a low albumin (normal 3.5–5.0 g/dL) can show a low total calcium while the active ionized calcium is fine. Check the albumin before you panic.
🧠 Low albumin fakes a low calcium. It is the single most common reason a calcium looks worse than the patient.
Figure 7 — the two named signs. Both are LOW calcium, and both also appear when magnesium is low or phosphate is high, because those drag calcium down.
🧘 MAGNESIUM — “magnesium mellows” (not in the BMP, but always nearby)
Range: 1.3–2.1 mEq/L — note the unit. Magnesium is reported in mEq/L on this site; some laboratories report it in mg/dL instead, so read the unit before you compare numbers.
LOW Mg²⁺The mellow is gone: hyperreflexia, tremor, seizures, and the top-tested rhythm — torsades de pointes and V-fib. Causes: malnourishment, chronic alcohol use, GI losses, diuretics.
HIGH Mg²⁺Super-mellow: absent deep tendon reflexes, depressed respirations, hypotension, bradycardia, heart block. Causes: renal failure, Mg-containing antacids and laxatives, IV magnesium.
Magnesium is ordered separately or as part of an extended panel — it is not one of the eight BMP values.
🧠 Check the DTRs. A disappearing reflex is the earliest warning that magnesium is climbing too high — before the breathing slows.
GO DEEPERAll six electrolytes side by side on NG-003 · All electrolytes cheat sheet (Renal + Fluid set) — the ranges on this page match it exactly.
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PART 4 · BUN : CREATININE
THE KIDNEY HALF
Two numbers that only mean something as a pair.
Figure 5 — where each marker comes from, and the ratio drawn as a balance. The tilt of the beam is the whole diagnosis.
🫘 BUN — the number that is easily fooled
Range: 10–20 mg/dL. Urea is protein waste: the liver turns ammonia into urea and the kidney excretes it.
Raised by things that are not the kidney: dehydration, a high-protein diet, GI bleeding (blood is protein), steroids, burns, and heart failure.
Lowered by: overhydration, liver failure (no urea is made), very low protein intake, pregnancy.
🧠 Think of a protein bar wrapper — urea is the packaging the body throws away after using the protein.
🧪 CREATININE — the kidney’s own handwriting
Range: 0.6–1.2 mg/dL. Muscle waste, produced at a steady rate by ordinary wear and tear, filtered and barely reabsorbed.
Over 1.3 = a hurt kidney.
Rising day on day = an injury happening right now.
Low muscle mass (older adults, amputees, prolonged bed rest) can hide kidney damage behind a “normal-looking” creatinine.
Pair it with urine output: under 30 mL/hr is kidney distress.
🧠 BUN can lie. Creatinine rarely does. When they disagree, believe the creatinine.
The patient is DRY. BUN climbs, creatinine barely moves. Dehydration, hemorrhage, shock, heart failure, vomiting and diarrhea. Fix the volume and the numbers come back.
10–15 : 1INTRA-RENAL
The kidney tissue is injured. Both climb together. Acute tubular necrosis, nephrotoxic drugs, glomerulonephritis, prolonged ischemia.
CHECKPOST-RENAL
Something is blocking the exit. Stone, enlarged prostate, tumor, clamped or kinked catheter. Bladder scan and check the hourly output before you assume the kidney has failed.
🧠 Dry · Damaged · Dammed. Three D’s, three places the problem can be: before the kidney, in it, or after it.
🚨 The renal-failure pattern you can predict
When the kidney fails, the panel moves in a predictable direction:
⬆ Potassium — cannot excrete it. This is the lethal one.
⬆ BUN and creatinine — cannot clear the waste.
⬆ Phosphate and ⬆ magnesium — cannot excrete them either.
⬇ Calcium — pushed down by the high phosphate, and the failing kidney cannot activate vitamin D.
A stress hyperglycemia in an acutely unwell client is common and does not by itself mean diabetes.
Remember the interaction with potassium: insulin drives potassium into cells, so treating a high glucose can drop the potassium.
🧠 Insulin moves sugar AND potassium into the cell. That is why it appears in the hyperkalemia protocol.
🧩 Four whole-panel patterns worth recognizing on sight
Panel
Think
Na ⬆ · BUN ⬆ · BUN:Cr > 20:1 · Hct ⬆
Dehydration. Everything looks concentrated because the water left.
K ⬆ · BUN ⬆ · Cr ⬆ · CO₂ ⬇ · Ca ⬇
Renal failure. The classic shape — waste up, base down, calcium down.
Glucose ⬆⬆ · K variable · CO₂ ⬇ · Na ⬇
DKA. Metabolic acidosis with a dilutional low sodium; total-body potassium is depleted even when the serum level looks normal.
K ⬇ · Cl ⬇ · CO₂ ⬆
Vomiting or NG suction. Losing acid and chloride → metabolic alkalosis.
🧠 Read a panel as a shape, not a list. Four shapes will carry you a long way.
✅ What you actually do with a BMP on shift
1Scan for the critical values first: potassium, sodium, glucose.
2Compare with yesterday. A trend beats a snapshot every time.
3Ask why it was ordered — new diuretic? new IV fluids? dialysis day?
4Look at the client: level of consciousness, respirations, reflexes, bowel sounds, urine output, daily weight.
5Hold or question any drug the result makes unsafe, and report with a recommendation.
🧠 Numbers, trend, reason, patient, action. Five steps, every panel, every shift.
🎯 Cover & check — 8 rapid-fire questions
Q1. Name the eight components of a BMP in fishbone order.Show answerSodium · chloride · BUN on the top row; potassium · CO₂ · creatinine on the bottom row; glucose on the point; calcium reported alongside.
Q2. BUN 48, creatinine 1.1. What is the ratio telling you?Show answerRoughly 44:1 — well over 20:1 with a normal creatinine. Pre-renal: the client is dry. Think dehydration, hemorrhage, heart failure.
Q3. Which tube does a BMP go in, and which tube must be filled exactly to the line?Show answerBMP: gold/SST or green. The one that must be filled to the line is the light blue citrate coagulation tube.
Q4. A potassium comes back at 6.4 on a client who had a difficult, traumatic draw. What do you do?Show answerReport it and redraw — both. Hemolysis can falsely raise potassium, but you never sit on a critical value while you wait.
Q5. What is the reference range for magnesium on this site, and in what unit?Show answer1.3–2.1 mEq/L. Note the unit — some laboratories report magnesium in mg/dL instead.
Q6. The CO₂ on a BMP is 18. Which acid–base disturbance does that suggest?Show answerA low bicarbonate → metabolic acidosis. Think DKA, renal failure, severe diarrhea, shock.
Q7. Total calcium is 7.8 and albumin is 2.4. Is the client necessarily hypocalcemic?Show answerNot necessarily. About half of blood calcium is bound to albumin, so a low albumin lowers the total calcium while the ionized calcium may be normal. Correlate with the client and the ionized level.
Q8. Your client’s potassium will not come up despite replacement. What do you check?Show answerThe magnesium. Low magnesium makes hypokalemia refractory.
🧪 The eightNa 135–145 · K 3.5–5.0 · Cl 97–107 · CO₂ 22–26 ·
BUN 10–20 · Cr 0.6–1.2 · glucose 70–110 · Ca 9.0–10.5. Typical adult ranges — check your lab.
💓 K⁺ firstPeaked T = HIGH · flat T + U = LOW.
Never IV push. Protect (calcium) → shift (insulin + D50) → remove (binder, dialysis).
🫘 RatioOver 20:1 = DRY.
10–15:1 with both up = the kidney is hurt. Then rule out an obstruction.
🧠 Units matterBMP CO₂ = bicarbonate in mEq/L (base,
kidneys). ABG PaCO₂ in mmHg (acid, lungs). Magnesium 1.3–2.1 mEq/L.